LASSE XIX, Avanzado
Comprendiendo y desafiando la refractariedad
Guadalajara, Mexico
23-28 de febrero de 2026
Programa
lunes, 23 de febrero de 2026
09:00Conferencia
What is refractory epilepsy? Historical overview
Conceptualization and Current Definition
09:20Evento Virtual
Current definition. Criticisms of the current concept of pharmaco resistance and new proposals
10:00Descanso
Break
10:30Trabajo en Grupo
Group work
12:30Descanso
Lunch
14:00Conferencia
What is pseudo-pharmaco resistance? Common diagnostic and therapeutic mistakes
Round table: Pseudo-pharmacoresistance
14:30Evento Virtual
Evaluation of pseudo-pharmacoresistance: video-EEG, diagnostic re-evaluation
15:00Taller
Hands-on Case Discussions: Predicting drug response in clinical scenarios
16:00Evento Virtual
Models to Predict Drug Response – Use of biomarkers, machine learning, and personalized medicine
Session & Workshop: Can we predict pharmacoresistance?
16:40Conferencia
Clinical factors that predict pharmacoresistance
17:20Taller
Translational Workshop: Integrating Mechanistic Knowledge into Treatment Plans
19:00Descanso
Dinner
martes, 24 de febrero de 2026
09:00Conferencia
Ion Channels in Epilepsy
09:45Conferencia
GABA and Glutamate Receptors
10:30Descanso
Break
11:00Evento Virtual
Synaptic vesicle proteins and other Mechanisms of Action
11:30Conferencia
What Other Diseases Can Teach Us About Reversing Pharmacoresistance
12:30Descanso
Lunch
14:00Conferencia
New Molecules and Future Therapies – Advances in rational drug design
14:45Conferencia
Roundtable: Challenges in Translating Mechanisms to Clinical Outcomes
16:00Descanso
Break
16:30Conferencia
Phases and costs of drug development
17:30Trabajo en Grupo
Meeting with tutors
20:30Descanso
Dinner
miércoles, 25 de febrero de 2026
09:00Conferencia
Drug Transporters and Efflux Systems
09:30Conferencia
Pharmacokinetic and Target-Related Mechanisms
10:00Evento Virtual
Pharmacogenomics and Personalized Medicine
10:30Descanso
Break
11:00Conferencia
Etiology associated factors
11:30Evento Virtual
Genetic basis
12:00Conferencia
Q&A Session
12:30Descanso
Lunch
14:00Conferencia
Microglia and Astrocyte Roles in Drug Resistant Epilepsy
14:30Conferencia
Mitochondrial Dysfunction, Oxidative Stress and Neuroinflammation
15:00Evento Virtual
Connectivity in the Epileptogenic Zone
15:30Descanso
Break
16:00Taller
Experimental Models of Pharmacoresistance
17:30Trabajo en Grupo
Meeting with tutors
19:30Descanso
Dinner
21:00Evento Social
Fiesta de las naciones
jueves, 26 de febrero de 2026
09:00Conferencia
Electrographic biomarkers of the DRE
09:30Conferencia
Predicting the outcome after epilepsy surgery
10:00Conferencia
Q&A Session
10:15Descanso
Break
10:30Evento Virtual
Corticosteroids and immunotherapy in epilepsy: past or future?
11:00Evento Virtual
Managing the diagnosis of DRE in the clinic: critical steps
11:30Conferencia
Gene therapy in epilepsy: the future is here
12:30Conferencia
Q&A Session
13:00Descanso
Lunch
14:00Taller
Parallel hands-on workshops: Simulation of drug response
18:30Descanso
Dinner
21:00Conferencia
Ethics in research
viernes, 27 de febrero de 2026
09:00Conferencia
Morbi-mortality of pharmaco-resistant epilepsy
09:30Conferencia
Psychiatric and cognitive comorbidity
10:00Conferencia
Impact on personal development and quality of life
10:30Descanso
Break
10:45Conferencia
Costs of epilepsy and pharmaco-resistant epilepsy
11:30Conferencia
Indirect costs of epilepsy from the patients’ perspective
12:00Conferencia
Q&A Session
12:30Descanso
Lunch
14:00Conferencia
Cost-effectiveness of antiseizure medications: a patient-centered perspective
14:30Conferencia
Cost-effectiveness of antiseizure medications: perspective of health and funding agencies
15:00Conferencia
Access to antiseizure medications and therapeutic gap in Latin America
15:30Descanso
Break
16:00Conferencia
Solution or delusion: originals vs. generics in epilepsy
16:30Conferencia
The role of funding and investment on pharmaceutical innovation
17:00Conferencia
Summary of contributions from the industry working group
18:00Conferencia
Discussion and proposals
sábado, 28 de febrero de 2026
09:00Trabajo en Grupo
Group Presentation
12:00Descanso
Lunch
13:30Trabajo en Grupo
Group Presentation
15:30Descanso
Break
16:00Evento Virtual
Bridging basic science, drug mechanisms, and resistance into clinical practice
16:30Evento Virtual
How new knowledge may reshape definitions of refractoriness
17:00Conferencia
Roundtable: Where do we go from here?
19:30Descanso
Dinner
21:00Evento Social
Farewell Party
Cuerpo Docente
Angel Aledo-Serrano
🇪🇸 España
Mario Alonso Vanegas
🇲🇽 México
Jerónimo Auzmendi
🇦🇷 Argentina
Giuseppe Bertini
🇮🇹 Italia
Marta Bertone
🇦🇷 Argentina
Alicia Bogacz
🇺🇾 Uruguay
Patricia Braga
🇺🇾 Uruguay
Jorge Burneo
🇨🇦 Canadá
Jaime Carrizosa
🇨🇴 Colombia
Esper Cavalheiro
🇧🇷 Brasil
Fernando Cendes
🇧🇷 Brasil
Guilca Contreras
🇻🇪 Venezuela
Jacqueline French
🇺🇸 Estados Unidos
María del Carmen García
🇦🇷 Argentina
Laura Hernández
🇲🇽 México
Katia Lin
🇧🇷 Brasil
Iscia Lopes-Cendes
🇧🇷 Brasil
Leonor López-Meraz
🇲🇽 México
Iris Martínez
🇲🇽 México
Laura Medina-Ceja
🇲🇽 México
Sandra Orozco-Suárez
🇲🇽 México
Jose Eduardo Peixoto-Santos
🇧🇷 Brasil
Luisa Rocha
🇲🇽 México
Rafael Naime Ruggiero
🇧🇷 Brasil
Loreto Ríos
🇨🇱 Chile
Helen Scharfman
🇺🇸 Estados Unidos
Francisco Taveras
🇩🇴 República Dominicana
Mónica E. Ureña-Guerrero
🇲🇽 México
Elvira Vacas
🇪🇸 España
Samuel Wiebe
🇨🇦 Canadá