LASSE XIX, Avançada
Compreendendo e desafiando a refratariedade
Guadalajara, Mexico
23-28 de fevereiro de 2026
Programa
segunda-feira, 23 de fevereiro de 2026
09:00Palestra
What is refractory epilepsy? Historical overview
Conceptualization and Current Definition
09:20Evento Virtual
Current definition. Criticisms of the current concept of pharmaco resistance and new proposals
10:00Intervalo
Break
10:30Trabalho em Grupo
Group work
12:30Intervalo
Lunch
14:00Palestra
What is pseudo-pharmaco resistance? Common diagnostic and therapeutic mistakes
Round table: Pseudo-pharmacoresistance
14:30Evento Virtual
Evaluation of pseudo-pharmacoresistance: video-EEG, diagnostic re-evaluation
15:00Workshop
Hands-on Case Discussions: Predicting drug response in clinical scenarios
16:00Evento Virtual
Models to Predict Drug Response – Use of biomarkers, machine learning, and personalized medicine
Session & Workshop: Can we predict pharmacoresistance?
16:40Palestra
Clinical factors that predict pharmacoresistance
17:20Workshop
Translational Workshop: Integrating Mechanistic Knowledge into Treatment Plans
19:00Intervalo
Dinner
terça-feira, 24 de fevereiro de 2026
09:00Palestra
Ion Channels in Epilepsy
09:45Palestra
GABA and Glutamate Receptors
10:30Intervalo
Break
11:00Evento Virtual
Synaptic vesicle proteins and other Mechanisms of Action
11:30Palestra
What Other Diseases Can Teach Us About Reversing Pharmacoresistance
12:30Intervalo
Lunch
14:00Palestra
New Molecules and Future Therapies – Advances in rational drug design
14:45Palestra
Roundtable: Challenges in Translating Mechanisms to Clinical Outcomes
16:00Intervalo
Break
16:30Palestra
Phases and costs of drug development
17:30Trabalho em Grupo
Meeting with tutors
20:30Intervalo
Dinner
quarta-feira, 25 de fevereiro de 2026
09:00Palestra
Drug Transporters and Efflux Systems
09:30Palestra
Pharmacokinetic and Target-Related Mechanisms
10:00Evento Virtual
Pharmacogenomics and Personalized Medicine
10:30Intervalo
Break
11:00Palestra
Etiology associated factors
11:30Evento Virtual
Genetic basis
12:00Palestra
Q&A Session
12:30Intervalo
Lunch
14:00Palestra
Microglia and Astrocyte Roles in Drug Resistant Epilepsy
14:30Palestra
Mitochondrial Dysfunction, Oxidative Stress and Neuroinflammation
15:00Evento Virtual
Connectivity in the Epileptogenic Zone
15:30Intervalo
Break
16:00Workshop
Experimental Models of Pharmacoresistance
17:30Trabalho em Grupo
Meeting with tutors
19:30Intervalo
Dinner
21:00Evento Social
Fiesta de las naciones
quinta-feira, 26 de fevereiro de 2026
09:00Palestra
Electrographic biomarkers of the DRE
09:30Palestra
Predicting the outcome after epilepsy surgery
10:00Palestra
Q&A Session
10:15Intervalo
Break
10:30Evento Virtual
Corticosteroids and immunotherapy in epilepsy: past or future?
11:00Evento Virtual
Managing the diagnosis of DRE in the clinic: critical steps
11:30Palestra
Gene therapy in epilepsy: the future is here
12:30Palestra
Q&A Session
13:00Intervalo
Lunch
14:00Workshop
Parallel hands-on workshops: Simulation of drug response
18:30Intervalo
Dinner
21:00Palestra
Ethics in research
sexta-feira, 27 de fevereiro de 2026
09:00Palestra
Morbi-mortality of pharmaco-resistant epilepsy
09:30Palestra
Psychiatric and cognitive comorbidity
10:00Palestra
Impact on personal development and quality of life
10:30Intervalo
Break
10:45Palestra
Costs of epilepsy and pharmaco-resistant epilepsy
11:30Palestra
Indirect costs of epilepsy from the patients’ perspective
12:00Palestra
Q&A Session
12:30Intervalo
Lunch
14:00Palestra
Cost-effectiveness of antiseizure medications: a patient-centered perspective
14:30Palestra
Cost-effectiveness of antiseizure medications: perspective of health and funding agencies
15:00Palestra
Access to antiseizure medications and therapeutic gap in Latin America
15:30Intervalo
Break
16:00Palestra
Solution or delusion: originals vs. generics in epilepsy
16:30Palestra
The role of funding and investment on pharmaceutical innovation
17:00Palestra
Summary of contributions from the industry working group
18:00Palestra
Discussion and proposals
sábado, 28 de fevereiro de 2026
09:00Trabalho em Grupo
Group Presentation
12:00Intervalo
Lunch
13:30Trabalho em Grupo
Group Presentation
15:30Intervalo
Break
16:00Evento Virtual
Bridging basic science, drug mechanisms, and resistance into clinical practice
16:30Evento Virtual
How new knowledge may reshape definitions of refractoriness
17:00Palestra
Roundtable: Where do we go from here?
19:30Intervalo
Dinner
21:00Evento Social
Farewell Party
Corpo Docente
Angel Aledo-Serrano
🇪🇸 Espanha
Mario Alonso Vanegas
🇲🇽 México
Jerónimo Auzmendi
🇦🇷 Argentina
Giuseppe Bertini
🇮🇹 Itália
Marta Bertone
🇦🇷 Argentina
Alicia Bogacz
🇺🇾 Uruguai
Patricia Braga
🇺🇾 Uruguai
Jorge Burneo
🇨🇦 Canadá
Jaime Carrizosa
🇨🇴 Colômbia
Esper Cavalheiro
🇧🇷 Brasil
Fernando Cendes
🇧🇷 Brasil
Guilca Contreras
🇻🇪 Venezuela
Jacqueline French
🇺🇸 Estados Unidos
María del Carmen García
🇦🇷 Argentina
Laura Hernández
🇲🇽 México
Katia Lin
🇧🇷 Brasil
Iscia Lopes-Cendes
🇧🇷 Brasil
Leonor López-Meraz
🇲🇽 México
Iris Martínez
🇲🇽 México
Laura Medina-Ceja
🇲🇽 México
Sandra Orozco-Suárez
🇲🇽 México
Jose Eduardo Peixoto-Santos
🇧🇷 Brasil
Luisa Rocha
🇲🇽 México
Rafael Naime Ruggiero
🇧🇷 Brasil
Loreto Ríos
🇨🇱 Chile
Helen Scharfman
🇺🇸 Estados Unidos
Francisco Taveras
🇩🇴 República Dominicana
Mónica E. Ureña-Guerrero
🇲🇽 México
Elvira Vacas
🇪🇸 Espanha
Samuel Wiebe
🇨🇦 Canadá